搜索结果: 1-15 共查到“医学 kinase”相关记录58条 . 查询时间(0.062 秒)
Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats
Neuropathic Pain Soleus Muscle CDK5 Protein Kinase
2015/11/6
Background: The relationship between decreased activity/neuropathic pain and gene expression alterations in soleus muscle has remained elusive.
Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice
Skeletal muscle eccentric contractions muscle damage CK activity
2015/8/28
Elevated plasma creatine kinase (CK) activity is often used as an
indicator of exercise-induced muscle damage. Our aim was to
study effects of contraction type, sex and age on CK efflux from
iso...
EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
hypoxia cancer HIF
2015/5/25
High choline uptake and increased choline kinase activity have been reported in many cancers. This has motivated the use of choline as a biomarker for tumor imaging. Tumors in general are heterogeneou...
PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYMES REGULATE DEATH ASSOCIATED PROTEIN KINASE (DAPK) IN CERAMIDE-INDUCED ANOIKIS
PROTEIN PHOSPHATASE 2A DAPK DEATH ASSOCIATED PROTEIN KINASE
2015/5/22
Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid produced by cells in response to i...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
THE ROLE OF DAP-KINASE IN MODULATING VASCULAR ENDOTHELIAL CELL FUNCTION UNDER FLUID SHEAR STRESS
DAP-K Mechano-transduction Apoptosis Shear Atherosclerosis
2015/1/12
Atherosclerosis preferentially develops in vascular regions of low or disturbed flow and high spatial gradients. Endothelial cells that line the vessel walls actively participate in translating mechan...
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
mast cells Pak1 allergic diseasis
2014/12/12
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
Dynamin Forms a Src Kinase–sensitive Complex with Cbl and Regulates Podosomes and Osteoclast Activity
dynamin osteoclast activity
2014/11/6
Podosomes are highly dynamic actin-containing adhesion structures found in osteoclasts, macrophages, and Rous sarcoma virus (RSV)-transformed fibroblasts. After integrin engagement, Pyk2 recruits Src ...
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
TrkB Alzheimer BACE1 SHC NFAT
2013/1/28
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has been reported that the...
Expression of 5′-AMP-activated Protein Kinase with Starvation in Murine Thymocytes
AMP-activated protein kinase Thymocyte Glucocorticoid
2011/6/10
The 5′-AMP-activated protein kinase (AMPK) is a key enzyme in the protection of cells during energy crisis. AMPK is a heterotrimer consisting of a catalytic α (α1, 2) subunit and two regulatory subuni...
The p21activated kinase 1 (PAK1) belongs to PAKs family, a group of highly evolutionarily conserved protein family of serine/threonine kinases, which acts as a downstream effector of the small GTPase...
目的：观察蟾蜍灵对人结肠癌细胞系增殖的抑制作用，并探讨其作用机理。 方法： 采用不同浓度的蟾蜍灵作用结肠癌SW-480细胞后，采用MTT法检测细胞的恶性增殖，分别采用琼脂糖凝胶电泳和流式细胞仪检测凋亡情况，分别采用Western blotting、Northern blotting分别检测polo-like kinase-1 (PLK1)蛋白、mRNA水平。 结果： 蟾蜍灵能抑制结肠癌细胞的恶性增...
Purification of Casein Kinase II From Lung Tissue and Kinetic Evaluations With Polyamines and Myc-Oncoprotein
Casein kinase II olyamines yc ell proliferation abbreviations KII-casein kinase II myc-phosphorylated myc oncoprotein Pmax-phosphorylated max protein
2009/7/2
The overall goal of this study was to seek molecular linkages between polyamines, casein kinase II, and the myc oncoprotein by using a cell-free, highly purified enzyme kinetic analysis. Casein kinase...
IFN-g-Mediated Transcriptional Induction of the IDO (Indolamine 2,3-Dioxygenase) Gene Requires Activity of p68/PKR Protein Kinase
IFN p68/PKR IDO transcription
2009/6/26
We investigated whether the activity of double-stranded RNA activated kinase (p68/PKR) is necessary for induction of IDO (indolamine 2,3 -dioxygenase) gene by IFN-g. For this purpose, we planned to ab...